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Molecular mechanism, binding free energy, and sequence selectivity of intercalation of doxorubicin and DNA
(2021)
Many drugs interact noncovalently with DNA either by groove binding or intercalation. Intercalation is a key process in drug discovery and biosensor development. Doxorubicin (DOX) is an intercalator drug that treats a wide ...
Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
(2014)
C. neoformans is an opportunistic fungal pathogen causing fatal meningitis and lung infections. Worldwide every year around 625,000 deaths occur due to Cryptococcosis. A basic understanding of Cryptococcus virulence ...
Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
(2013)
Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset ...
Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
(2020)
It has been well documented that the onset of menopause correlates with an increase in the onset of neurodegenerative diseases such as Alzheimer’s disease. Estrogen supplementation was used as treatment/prevention for a ...
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
(2014)
Expansion of high-throughput sequencing technology has increased our understanding
in the importance of pervasive transcription and the resulting indispensable molecules, noncoding
RNAs (ncRNAs). A significant effort has ...